Tramadol is an extremely popular analgesic. In many nations, Tramadol is not treated as a controlled substance, in contrast to other opioids.

Adopted as an analgesic since the end of the 1970s, Tramadol has turned into one of the most sought after analgesics of its category in Germany. When it was discovered that Tramadol inhibits serotonin and noradrenaline reuptake, in addition to behaving like an opioid, international interest in this drug increased.

How Tramadol Works

Tramadol is an unusual drug. It differs from other opioids in its safety feature as well as in the way it works. Categorized as an atypical centrally acting analgesic, it possesses both opioid and non-opioid characteristics. Being a synthetic analogue to codeine, Tramadol has some weak opioid receptor qualities. Like antidepressant drugs, Tramadol inhibits the neuronal reuptake of serotonin and norephinephrine.

Tramadol has similar structural properties to venlafaxine, an antidepressant. Patients who suffer from chronic pain may experience an antidepressant outcome from using this medicine.

Side Effects

Most people tolerate Tramadol well, but nausea and vomiting being the most frequent side effects. Respiratory depression is uncommon using Tramadol treatments of equal strength as compared to morphine or pethidine. The respiratory effects, though, of other drugs may be increased with high doses of Tramadol. Much less dizziness or drowsiness occurs with Tramadol than when using morphine, though there has been noted a low incidence rate of cardiac depression.

In the final analysis, dependency and abuse are not an issue when taking Tramadol, due to the fact that Tramadol does not have a strong opioid effect. Post-marketing observation indicates that Tramadol has a low potential for abuse.

Compared with other opioids, Tramadol has similar urinary tract risks, such as urinary retention and difficulty in micturition.

People who are taking medicine to lower epileptic seizure levels should be cautious about using Tramadol; people with epilepsy should not take Tramadol at all.

How Tramadol is Utilized

Tramadol can be effectively used to treat moderate to severe pain, and can also be used to treat neuropathic pain. This medicine has a parenteral strength similar to that of pethidine, and the success of a dependent dose is somewhere between the efficacy of codeine and morphine.

Treatment for post operative pain is more effective when using Tramadol than when using NSAIDs. Tramadol’s method of operation does not interfere with the NSAID group of pain and inflammation medications, which allows it to be used in combination with those drugs. The incidence of side effects can be cut down by combining Tramadol with NSAIDs, which permits a lowered Tramadol dose.

Tramadol is a good medication for elderly people who have osteoarthritis because, contrary to the effects of nonsteroidal anti-inflammatory medications, Tramadol does not cause high blood pressure or other cardiovascular complications, nor does Tramadol have the ability to cause peptic ulcers.

Tramadol has been used successfully to manage labor pains without resorting to respiratory depression of the neonate. It can effectively treat pain that occurs due to myocardial ischaemia, renal colic and acute trauma.


It is recommended that Tramadol be taken every 4 to 6 hours at a dosage between 50 mg and 100 mg, and the maximum dosage of Tramadol that is taken on a daily basis should not exceed 400 mg; the length of time of an analgesic effect following one dose of 100mg of Tramadol is approximately 6 hours.